| Matches by round |
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
| Match list: | By round By date Latest | Player stats: |
| R | Date | Home | Score | Away | Time | Location | |
| 1 | 11/04/2010 | Knox United | 4 - 0 | Mooroolbark C | 15:00 | ||
| 2 | 18/04/2010 | Baxter Owls | 0 - 9 | Knox United | 11:00 | ||
| 3 | 25/04/2010 | Knox United | 2 - 6 | Mooroolbark B | 15:00 | ||
| 4 | 2/05/2010 | Knox United | 3 - 2 | Boronia Barons | 15:00 | ||
| 5 | 16/05/2010 | Seaford United | 2 - 2 | Knox United | 13:00 | ||
| 6 | 23/05/2010 | Knox United | 1 - 4 | Mornington Prts | 15:00 | ||
| 7 | 30/05/2010 | Langwarrin C | 1 - 2 | Knox United | 15:00 | ||
| 8 | 6/06/2010 | Bayswater C | 2 - 2 | Knox United | 11:00 | ||
| 9 | 20/06/2010 | Knox United | 5 - 2 | Mountainmen | 15:00 | ||
| 11 | 11/07/2010 | Knox United | 5 - 0 | Baxter Owls | 15:00 | ||
| 12 | 18/07/2010 | Mooroolbark B | 5 - 0 | Knox United | 15:00 | ||
| 13 | 25/07/2010 | Boronia Barons | 0 - 5 | Knox United | 13:00 | ||
| 14 | 8/08/2010 | Knox United | 6 - 2 | Seaford United | 15:00 | ||
| 15 | 15/08/2010 | Mornington Prts | 2 - 0 | Knox United | 13:00 | ||
| 10 | 22/08/2010 | Mooroolbark C | 2 - 4 | Knox United | 15:00 | ||
| 16 | 29/08/2010 | Knox United | 2 - 2 | Langwarrin C | 15:00 | ||
| 17 | 5/09/2010 | Knox United | 2 - 1 | Bayswater C | 15:00 | ||
| 18 | 12/09/2010 | Mountainmen | 0 - 3 | Knox United | 13:00 |